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Gut–brain axis in 2016

Brain–gut–microbiota axis — mood, metabolism and behaviour

In 2016, key studies have increased our understanding of the part played by the brain–gut–microbiota axis in disorders as diverse as depression, obesity and autism spectrum disorder. The data indicate that alterations in gut-microbial composition can substantially affect central physiology, and that transplantation of the gut microbiota can transfer a behavioural or physiological phenotype.

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Figure 1: The brain–gut–microbiota axis.


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Correspondence to Timothy G. Dinan.

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Dinan, T., Cryan, J. Brain–gut–microbiota axis — mood, metabolism and behaviour. Nat Rev Gastroenterol Hepatol 14, 69–70 (2017).

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