Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IBD

A timely diagnosis of primary sclerosing cholangitis in IBD

Nature Reviews Gastroenterology & Hepatology volume 13, pages 565–566 (2016)Cite this article

Subjects

Although a colonoscopy for the evaluation of IBD and the surveillance of colitis-associated neoplasia should be performed at the time of the diagnosis of primary sclerosing cholangitis (PSC), the results from a new study suggest that screening for PSC with magnetic resonance cholangiography in patients with long-term IBD might be needed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A proposed model for the disease spectrum and overlaps of immune-mediated disorders of the gut and liver.

References

  1. European Association for the Study of the Liver. EASL clinical practice guidelines: management of cholestatic liver diseases. J. Hepatol. 51, 237–267 (2009).

  2. Lunder, A. K. et al. Prevalence of sclerosing cholangitis, detected by magnetic resonance cholangiography, in patients with long-term inflammatory bowel disease. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2016.06.021 (2016).

  3. Loftus, E. V. Jr et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut. 54, 91–96 (2005).

    Article  Google Scholar 

  4. Navaneethan, U. & Shen, B. Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. Inflamm. Bowel Dis. 16, 1598–1619 (2010).

    Article  Google Scholar 

  5. Soetikno, R. M., Lin, O. S., Heidenreich, P. A., Young, H. S. & Blackstone, M,O. Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis. Gastrointest. Endosc. 56, 48–54 (2002).

    Article  Google Scholar 

  6. Lindor, K. D., Kowdley, K. V. & Harrison, E. M. ACG clinical guideline: primary sclerosing cholangitis. Am. J. Gastroenterol. 110, 646–659 (2015).

    Article  CAS  Google Scholar 

  7. Kornbluth, A., Sachar, D. B. & Practice Parameters Committee of the American College of Gastroenterology. Ulcerative colitis practice guidelines in adults. Am. J. Gastroenterol. 105, 501–523 (2010).

    Article  Google Scholar 

  8. Farraye, F. A. et al. AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology 138, 738–745 (2010).

    Article  Google Scholar 

  9. Cairns, S. R. et al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut 59, 666–689 (2010).

    Article  Google Scholar 

  10. Annese, V. et al. European evidence based consensus endoscopy in inflammatory bowel disease. J. Crohns Colitis 7, 982–1018 (2013).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Center for Inflammatory Bowel Diseases, Digestive Disease and Surgery Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Bo Shen

Authors
  1. Bo Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bo Shen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shen, B. A timely diagnosis of primary sclerosing cholangitis in IBD. Nat Rev Gastroenterol Hepatol 13, 565–566 (2016). https://doi.org/10.1038/nrgastro.2016.130

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2016.130

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing