A recent study reports that being overweight in late adolescence is associated with an increased risk of liver-related morbidity and mortality later in life. These findings give further strength to the concerns for the deleterious effects of childhood obesity on liver health. Early prevention by screening and lifestyle modification should be advised by health policies.
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Waist-to-height ratio associated cardiometabolic risk phenotype in children with overweight/obesity
BMC Public Health Open Access 15 August 2023
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References
Kelly, T., Yang, W., Chen, C. S., Reynolds, K. & He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. 32, 1431–1437 (2008).
Yki-Järvinen, H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2, 901–910 (2014).
Bhala, N., Jouness, R. I. & Bugianesi, E. Epidemiology and natural history of patients with NAFLD. Curr. Pharm. Des. 19, 5169–5176 (2013).
Ogden, C. L., Carroll, M. D., Kit, B. K. & Flegal, K. M. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA 307, 483–490 (2012).
Hagström, H., Stål, P., Hultcrantz, R., Hemmingsson, T. & Andreasson, A. Overweight in late adolescence predicts development of severe liver disease later in life: a 39 years follow-up study. J. Hepatol. 65, 363–368 (2016).
Zimmermann, E. et al. Body mass index in school-aged children and the risk of routinely diagnosed non-alcoholic fatty liver disease in adulthood: a prospective study based on the Copenhagen School Health Records Register. BMJ Open 5, e006998 (2015).
Suomela, E. et al. Childhood predictors of adult fatty liver. The Cardiovascular Risk Young Finns Study. J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2016.05.020 (2016).
Berentzen, T. L., Gamborg, M., Holst, C., Sorensen, T. I. & Baker, J. L. Body mass index in childhood and adult risk of primary liver cancer. J. Hepatol. 60, 325–330 (2014).
Hassan, M. M. et al. Obesity early in adulthood increases risk but does not affect outcomes of hepatocellular carcinoma. Gastroenterology 149, 119–129 (2015).
European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol. 64, 1388–1402 (2016).
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Marietti, M., Bugianesi, E. Childhood obesity: time bomb for future burden of chronic liver disease. Nat Rev Gastroenterol Hepatol 13, 506–507 (2016). https://doi.org/10.1038/nrgastro.2016.120
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DOI: https://doi.org/10.1038/nrgastro.2016.120
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Waist-to-height ratio associated cardiometabolic risk phenotype in children with overweight/obesity
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