The cells responsible for particular gene signatures in large-scale microarray studies of colorectal cancer have now been revealed. In doing so, the gene signature associated with poor prognosis is shown to be predominantly of stromal origin.
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Acknowledgements
The authors would like to thank H. Yamamoto, N. Nishida, A. Hamabe and H. Ishii for their intellectual input.
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Colvin, H., Mori, M. Back to the stroma—the real villain in colorectal cancer?. Nat Rev Gastroenterol Hepatol 12, 256–258 (2015). https://doi.org/10.1038/nrgastro.2015.57
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DOI: https://doi.org/10.1038/nrgastro.2015.57
