Patients with biopsy-proven NAFLD (n = 57) have gut dysbiosis related to the severity of their disease, according to a new study published in Hepatology. Abundance of the genus Bacteroides was increased in patients with NASH and those with marked fibrosis. Patients with fibrosis also had an increased abundance of Ruminococcus. In an adjusted multivariate analysis, Bacteroides abundance was independently associated with presence of NASH and fibrosis, and Ruminococcus abundance was independently associated with fibrosis.
References
Boursier, J. et al. The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 10.1002/hep.28356
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Thomas, H. NAFLD severity associated with gut dysbiosis. Nat Rev Gastroenterol Hepatol 13, 2 (2016). https://doi.org/10.1038/nrgastro.2015.212
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DOI: https://doi.org/10.1038/nrgastro.2015.212
