Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer. In a new retrospective study published in Gut, IJspeert and colleagues found that the 5-year cumulative incidence of colorectal cancer during surveillance in patients who had all SPS lesions cleared (n = 260) was 1.5%, lower than the 6.5% cumulative incidence the authors had reported in a previous smaller study. In addition, the researchers found that a history of smoking was associated with a reduced risk of colorectal cancer (OR 0.36, P <0.001).
References
IJspeert, J. E. G. et al. Clinical risk factors of colorectal cancer in patients with serrated polyposis syndrome: a multicentre cohort analysis. Gut 10.1136/gutjnl-2015-310630
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Thomas, H. Serrated polyposis syndrome and colorectal cancer. Nat Rev Gastroenterol Hepatol 13, 2 (2016). https://doi.org/10.1038/nrgastro.2015.211
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DOI: https://doi.org/10.1038/nrgastro.2015.211
