The environmental determinants of disease have been studied in a prospective birth cohort study, TEDDY, of children (n = 6,436) with high-risk HLA genotypes for coeliac disease. During a follow-up of 5 years, 12% of children tested positive for the coeliac disease marker tissue transglutaminase autoantibodies. Coeliac disease developed in 5% of the children. However, the timing of gluten introduction was not found to be an independent risk factor for coeliac disease.
References
Aronsson, C. A. et al. Age at gluten introduction and risk of coeliac disease. Pediatrics 10.1542/peds.2014-1787
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Age at gluten introduction is not an independent risk factor for coeliac disease. Nat Rev Gastroenterol Hepatol 12, 123 (2015). https://doi.org/10.1038/nrgastro.2015.19
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DOI: https://doi.org/10.1038/nrgastro.2015.19
