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Gut microbiota

Ganoderma lucidum, a new prebiotic agent to treat obesity?

Modulation of the gut microbiota is one of the promising tools to tackle obesity. Chang and colleagues have recently shown that an extract of the mushroom Ganoderma lucidum, a traditional remedy in Asia, can reduce obesity in mice by modulating the gut microbiota, thereby exerting a prebiotic effect.

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Figure 1: Metabolic improvements conferred by WEGL administration to obese mice.

References

  1. Bindels, L. B., Delzenne, N. M., Cani, P. D. & Walter, J. Towards a more comprehensive concept for prebiotics. Nat. Rev. Gastroenterol. Hepatol. 12, 303–310 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Chang, C. J. et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat. Commun. 6, 7489 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Klupp, N. L. et al. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database of Systematic Reviews Issue 2. Art. No.: CD007259 http://dx.doi.org/10.1002/14651858.CD007259.pub2.

  4. Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761–1762 (2007).

    CAS  PubMed  Google Scholar 

  5. Cani, P. D. et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 1470–1481 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Gao, Z. et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58, 1509–1517 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337–341 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Kuipers, F., Bloks, V. W. & Groen, A. K. Beyond intestinal soap—bile acids in metabolic control. Nat. Rev. Endocrinol. 10, 488–498 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Salonen, A. et al. Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men. ISME. J. 8, 2218–2230 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dao, M. C. et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut http://dx.doi.org/10.1136/gutjnl-2014-308778.

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Acknowledgements

N.M.D. is a recipient of IWT subsidies and grants from the FRS-FNRS, the Walloon Region and the European Union's Seventh Framework Program community. L.B.B. is a postdoctoral fellow from the FRS-FNRS.

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Correspondence to Nathalie M. Delzenne.

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Delzenne, N., Bindels, L. Ganoderma lucidum, a new prebiotic agent to treat obesity?. Nat Rev Gastroenterol Hepatol 12, 553–554 (2015). https://doi.org/10.1038/nrgastro.2015.137

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