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Gut microbiota

Microbiota and neuroimmune signalling—Metchnikoff to microglia

The role of the gut microbiota in brain development and behaviour is emerging. New research demonstrates that maturation and activation of microglia are regulated by the gut microbiota, providing more evidence for the link between the microbiota and brain health.

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Figure 1: Mechanisms for microbiota regulation of neuroimmune signalling.


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The authors would like to acknowledge the assistance of Dr R. Stilling, APC Microbiome Institute, Ireland, for his design of Figure 1 and helpful comments on the paper.

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Correspondence to John F. Cryan.

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T.G.D. and J.F.C. are principal investigators in the Alimentary Pharmabiotic Centre (APC), University College Cork. The APC has conducted research funded by Cremo, GlaxoSmithKline, Mead Johnson, Pfizer, Proctor & Gamble and Suntory Wellness. J.F.C. has been an invited speaker at meetings organized by Alkermes, Janssen, Mead Johnson and Yakult. T.G.D. has been an invited speaker at meetings organized by AstraZeneca, Lundbeck, Janssen and Servier.

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Cryan, J., Dinan, T. Microbiota and neuroimmune signalling—Metchnikoff to microglia. Nat Rev Gastroenterol Hepatol 12, 494–496 (2015).

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