Antifibrotic therapies are urgently needed to treat liver fibrosis. Now, researchers have shown that a small interfering RNA against the procollagen α1(I) gene packaged into a lipid-like nanoparticle (LNP-siCol1a1) can reduce experimental liver fibrosis in mice with progressive and advanced disease. Intravenous injection of LNP-siCol1a1 led to suppression of procollagen α1(I) expression (up to 90%) and decreased collagen deposition (by 40–60%). Moreover, regression of liver fibrosis was induced and progression of fibrosis inhibited.
References
Jiménez Calvente, C. et al. Specific hepatic delivery of procollagen α1(I) siRNA in lipid-like nanoparticles resolves liver fibrosis. Hepatology 10.1002/hep.27936
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siRNA-loaded nanoparticles resolve liver fibrosis in mice. Nat Rev Gastroenterol Hepatol 12, 428 (2015). https://doi.org/10.1038/nrgastro.2015.122
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DOI: https://doi.org/10.1038/nrgastro.2015.122
