A panel of gene expression and serological markers in combination with psychological measures can differentiate patients with IBS from healthy individuals, as well as between subtypes of IBS. A combination of 34 markers and psychological measures differentiated between 168 patients with IBS and 76 individuals with no functional gastrointestinal disorder. The biological markers also gave good discrimination between IBS subtypes (60 IBS-C, 57 IBS-D and 51 mixed). The authors conclude that this is “exciting progress towards a diagnostic test for IBS”.
References
Jones, M. P. et al. A biomarker panel and psychological morbidity differentiates the irritable bowel syndrome from health and provides novel pathophysiological leads. Aliment. Pharmacol. Ther. 10.1111/apt.12608
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A combination of biomarkers could aid IBS diagnosis. Nat Rev Gastroenterol Hepatol 11, 74 (2014). https://doi.org/10.1038/nrgastro.2014.5
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DOI: https://doi.org/10.1038/nrgastro.2014.5
