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NAFLD

Metabolic make-up of NASH: from fat and sugar to amino acids

Nature Reviews Gastroenterology & Hepatology volume 11, pages 205207 (2014) | Download Citation

NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment.

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Acknowledgements

The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04 (Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET).

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Affiliations

  1. Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina.

    • Silvia Sookoian
  2. Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina.

    • Carlos J. Pirola

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Silvia Sookoian.

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DOI

https://doi.org/10.1038/nrgastro.2014.25

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