Metabolic make-up of NASH: from fat and sugar to amino acids

NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment.

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Figure 1: Proposed hypothesis regarding metabolic changes associated with NAFLD progression and the prediction of protein–chemical interactions based on metabolic modelling.


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The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04 (Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET).

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Correspondence to Silvia Sookoian.

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The authors declare no competing financial interests.

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Sookoian, S., Pirola, C. Metabolic make-up of NASH: from fat and sugar to amino acids. Nat Rev Gastroenterol Hepatol 11, 205–207 (2014).

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