Two papers in the New England Journal of Medicine have looked at the intussusception risk in US infants after rotavirus vaccination. Weintraub et al. report an estimated attributable risk of intussusception after two doses of monovalent vaccine of 5.3 per 100,000 infants vaccinated. Yih et al. reported that the first dose of pentavalent vaccine was associated with 1.5 excess cases of intussusception per 100,000 infants vaccinated. Secondary analysis suggested a potential risk with monovalent vaccine, but this part of the study was underpowered. Both groups stress the need to view the risk in light of the benefits of vaccination.
References
Weintraub, E. S. et al. Risk of intussusception after monovalent rotavirus vaccination. New Engl. J. Med. 10.1056/NEJMoa1311738
Yih, W. K. et al. Intussusception risk after rotavirus vaccination in U.S. infants. N. Engl. J. Med. 10.1056/NEJMoa1303164
Rights and permissions
About this article
Cite this article
Rotavirus vaccination and risk of intussusception. Nat Rev Gastroenterol Hepatol 11, 140 (2014). https://doi.org/10.1038/nrgastro.2014.24
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2014.24