A study published in The Journal of Clinical Investigation has demonstrated the potential of a novel mouse model of HCV infection. Hepatocyte-like cells (HLCs) differentiated from human embryonic stems cells and induced pluripotent stem cells were engrafted in the liver parenchyma of immune-deficient mice. These HLCs were then found to undergo further maturation and could support long-term infection of multiple HCV genotypes, thus providing a new way to study the biology of chronic HCV infection in patient-derived hepatocytes.