A study published in The Journal of Clinical Investigation has demonstrated the potential of a novel mouse model of HCV infection. Hepatocyte-like cells (HLCs) differentiated from human embryonic stems cells and induced pluripotent stem cells were engrafted in the liver parenchyma of immune-deficient mice. These HLCs were then found to undergo further maturation and could support long-term infection of multiple HCV genotypes, thus providing a new way to study the biology of chronic HCV infection in patient-derived hepatocytes.
References
Carpentier, A. et al. Engrafted human stem-cell derived hepatocytes establish an infectious HCV murine model. J. Clin. Invest. 10.1172/JCI75456
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A new model to study chronic HCV infection. Nat Rev Gastroenterol Hepatol 11, 702 (2014). https://doi.org/10.1038/nrgastro.2014.191
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DOI: https://doi.org/10.1038/nrgastro.2014.191