A new study suggests that co-prescription of low-dose aspirin and PPIs increases the incidence of small-bowel mucosal breaks. Should we be concerned about the potential negative interactions of these drugs? Or is the balance of evidence still substantially tipped towards the need for PPIs to protect against aspirin-induced upper gastrointestinal damage?
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A.L. has received funding from Astra-Zeneca, Bayer and Pfizer. C.S. declares no competing interests.
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Lanas, A., Sostres, C. The small bowel, low-dose aspirin and PPIs—should we be concerned?. Nat Rev Gastroenterol Hepatol 11, 458–460 (2014). https://doi.org/10.1038/nrgastro.2014.120
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DOI: https://doi.org/10.1038/nrgastro.2014.120
