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Sorafenib: no effect on efficacy of chemotherapy in pancreatic cancer

Nature Reviews Gastroenterology & Hepatology volume 11, pages 89 (2014) | Download Citation

Targeting angiogenesis has not been successful as a treatment for pancreatic cancer. Studies using monoclonal antibodies or small molecule inhibitors of the VEGFR pathway have failed to demonstrate benefit. Now, a phase II study has shown that sorafenib does not improve the efficacy of gemcitabine plus cisplatin chemotherapy in patients with locally advanced or metastatic pancreatic adenocarcinoma.

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Affiliations

  1. Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA.

    • Muhammad Wasif Saif

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  1. Search for Muhammad Wasif Saif in:

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The author declares no competing financial interests.

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Correspondence to Muhammad Wasif Saif.

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DOI

https://doi.org/10.1038/nrgastro.2013.234

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