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Colorectal cancer

CRC—all about microbial products and barrier function?

Nature Reviews Gastroenterology & Hepatology volume 9, pages 694–696 (2012)Cite this article

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Novel findings draw attention to the adverse effect that neoplastic transformation of epithelial cells has on intestinal barrier function and cancer progression. An impaired intestinal barrier facilitated the translocation of microbial products, which promoted cytokine production and subsequent tumour progression in mice. The findings could open new therapeutic avenues for patients with early stage colorectal cancer.

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Figure 1: Interplay between the intestinal milieu, host inflammatory responses and colorectal cancer.

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Acknowledgements

The author would like to acknowledge grant support from the NIH, grants DK047700 and DK073338.

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  1. Department of Medicine, Pharmacology, Immunology–Microbiology, University of North Carolina, 111 Mason Farm Road, 7341B Medical Biomolecular Research Building, Chapel Hill, 27599, NC, USA

    Christian Jobin

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  1. Christian Jobin
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Jobin, C. CRC—all about microbial products and barrier function?. Nat Rev Gastroenterol Hepatol 9, 694–696 (2012). https://doi.org/10.1038/nrgastro.2012.220

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