Previous clinical trials have failed to conclude whether preoperative infliximab increases early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery. A meta-analysis including 13 studies and 2,933 patients has now confirmed that preoperative infliximab therapy has no significant effect on the rate of infectious or noninfectious complications in these patients (P = 0.81 and P = 0.61, respectively).
ORIGINAL RESEARCH PAPER
Yang, Z. et al. Meta-analysis: effect of preoperative infliximab use on early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery. Aliment. Pharmacol. Ther. doi:10.1111/apt.12060
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Effect of preoperative infliximab on postoperative complications in patients with ulcerative colitis. Nat Rev Gastroenterol Hepatol 9, 687 (2012). https://doi.org/10.1038/nrgastro.2012.204