Metagenomic and metabonomic analysis suggests that age-associated stability of the intestinal ecosystem is strongly influenced by an individual's social and dietary status. The process of immunosenescence might serve as a causal link to explain the association between a perturbed distal gut microbiota and frailty in the elderly.
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The authors declare no competing financial interests.
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Kinross, J., Nicholson, J. Dietary and social modulation of gut microbiota in the elderly. Nat Rev Gastroenterol Hepatol 9, 563–564 (2012). https://doi.org/10.1038/nrgastro.2012.169
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