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Cancer

Subsite differences in colorectal cancer—anything new?

Although a great deal is known about the environmental and genetic causes of colorectal cancer, it is still one of the most common cancers in the world. A new German study including >17,500 patients focuses on differences between proximal and distal disease. Is there anything new from this study that could help us further understand the etiology of colorectal cancer and improve the screening and management of this disease?

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References

  1. Potter, J. D. & Hunter, D. J. in Genetics of Colorectal Cancer (eds Potter, J. & Lindor, N.) 5–25 (Springer, New York, 2009).

    Book  Google Scholar 

  2. McMichael, A. J. & Potter, J. D. Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J. Natl Cancer Inst. 65, 1201–1207 (1980).

    CAS  PubMed  Google Scholar 

  3. Chlebowski, R. T. et al. Estrogen plus progestin and colorectal cancer in postmenopausal women. N. Engl. J. Med. 350, 991–1004 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. McMichael, A. J. & Potter, J. D. Host factors in carcinogenesis: certain bile-acid metabolic profiles that selectively increase the risk of proximal colon cancer. J. Natl Cancer Inst. 75, 185–191 (1985).

    CAS  PubMed  Google Scholar 

  5. Jass, J. in Genetics of Colorectal Cancer (eds Potter, J. & Lindor, N.) 97–121 (Springer, New York, 2009).

    Book  Google Scholar 

  6. Benedix, F. et al. Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis. Colon Rectum 53, 57–64 (2010).

    Article  PubMed  Google Scholar 

  7. Morimoto, L. M. et al. Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol. Biomarkers Prev. 11, 1012–1018 (2002).

    PubMed  Google Scholar 

  8. Slattery, M. L. et al. Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J. Natl Cancer Inst. 92, 1831–1836 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Giovannucci, E. et al. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J. Natl Cancer Inst. 87, 265–273 (1995).

    Article  CAS  PubMed  Google Scholar 

  10. Breast and Colon Cancer Family Registries. National Cancer Institute [online], (2010).

Download references

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Potter, J. Subsite differences in colorectal cancer—anything new?. Nat Rev Gastroenterol Hepatol 7, 248–249 (2010). https://doi.org/10.1038/nrgastro.2010.48

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