Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

IBS in 2010

Advances in pathophysiology, diagnosis and treatment

Nature Reviews Gastroenterology & Hepatology volume 8, pages 76–78 (2011)Cite this article

Subjects

IBS is a chronic, fluctuating disorder that continues to be the subject of considerable research. 2010 saw some key advances across all aspects of IBS, including further advances in our understanding of the pathophysiology, diagnosis and treatment of this condition.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Proposed etiological mechanisms in IBS.

References

  1. Mertz, H. et al. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. Gastroenterology 118, 842–848 (2000).

    Article  CAS  Google Scholar 

  2. Bonaz, B. et al. Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. Am. J. Gastroenterol. 97, 654–661 (2002).

    Article  CAS  Google Scholar 

  3. Tillisch, K., Mayer, E. A. & Labus, J. S. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology doi:10.1053/j.gastro.2010.07.053 (2010).

  4. Thabane, M., Kottachchi, D. & Marshall, J. K. Systematic review and meta-analysis: incidence and prognosis of post-infectious irritable bowel syndrome. Aliment. Pharmacol. Ther. 26, 535–544 (2007).

    Article  CAS  Google Scholar 

  5. Marshall, J. K. et al. Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery. Gut 59, 605–611 (2010).

    Article  Google Scholar 

  6. Chey, W. D. et al. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am. J. Gastroenterol. 105, 859–865 (2010).

    Article  Google Scholar 

  7. Lembo, A. J. et al. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology 138, 886–895 (2010).

    Article  CAS  Google Scholar 

  8. Johnston, J. M. et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome. Gastroenterology doi:10.1053/j.gastro.2010.08.041 (2010).

  9. Klooker, T. K. et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59, 1213–1221 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leeds Gastroenterology Institute, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK

    Alexander C. Ford

  2. Faculty of Health, University of Newcastle, University Drive, Callaghan, 2308, NSW, Australia

    Nicholas J. Talley

Authors
  1. Alexander C. Ford
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicholas J. Talley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexander C. Ford.

Ethics declarations

Competing interests

N. J. Talley has acted as a consultant for Ironwood Pharmaceuticals and Novartis. A. C. Ford declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ford, A., Talley, N. Advances in pathophysiology, diagnosis and treatment. Nat Rev Gastroenterol Hepatol 8, 76–78 (2011). https://doi.org/10.1038/nrgastro.2010.216

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2010.216

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing