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Hepatitis

Hepatitis E vaccination—is HEV 239 the breakthrough?

Nature Reviews Gastroenterology & Hepatology volume 8, pages 8–10 (2011)Cite this article

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No approved vaccine is currently available against hepatitis E virus (HEV), which can cause acute hepatitis E. A large-scale phase III study involving more than 100,000 Chinese adults has reported that the recombinant HEV vaccine, HEV 239, prevented acute hepatitis E with a vaccine efficacy of 94–100%.

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References

  1. Purcell, R. H. & Emerson, S. U. Hepatitis E: an emerging awareness of an old disease. J. Hepatol. 48, 494–503 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Navaneethan, U., Al Mohajer, M. & Shata, M. T. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int. 28, 1190–1199 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Radha Krishna, Y. et al. Clinical features and predictors of outcome in acute hepatitis A and hepatitis E virus hepatitis on cirrhosis. Liver Int. 29, 392–398 (2009).

    Article  PubMed  Google Scholar 

  4. Pischke, S. & Wedemeyer, H. Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterol. Dietol. 56, 121–128 (2010).

    CAS  PubMed  Google Scholar 

  5. Pischke, S. et al. Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients. Liver Transpl. 16, 74–82 (2010).

    Article  PubMed  Google Scholar 

  6. Zhu, F. C. et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 376, 895–902 (2010).

    Article  CAS  PubMed  Google Scholar 

  7. Shrestha, M. P. et al. Safety and efficacy of a recombinant hepatitis E vaccine. N. Engl. J. Med. 356, 895–903 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Zhang, J. et al. Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine. Vaccine 27, 1869–1874 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. Pischke, S. et al. Should all patients with autoimmune hepatitis be screened for HEV-infection [abstract]? J. Hepatol. 52 (Suppl. 1), S135 (2010).

    Article  Google Scholar 

  10. Kamar, N. et al. Ribavirin therapy inhibits viral replication on patients with chronic hepatitis E virus infection. Gastroenterology 139, 1612–1618 (2010).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by a grant from the German Federal Ministry of Education and Research (01EO0802).

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  1. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, 30625, Germany

    Heiner Wedemeyer & Sven Pischke

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  1. Heiner Wedemeyer
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  2. Sven Pischke
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Correspondence to Heiner Wedemeyer.

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The authors declare no competing financial interests.

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Wedemeyer, H., Pischke, S. Hepatitis E vaccination—is HEV 239 the breakthrough?. Nat Rev Gastroenterol Hepatol 8, 8–10 (2011). https://doi.org/10.1038/nrgastro.2010.207

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