Pancreas

Alcoholic pancreatitis—it's the alcohol, stupid

The management of alcoholic pancreatitis is mostly reactive; little is done to prevent disease progression. It is time for physicians to pay attention to the root cause of the condition—that is, alcohol—rather than just responding to its effects. This article discusses an important paper that describes the first prospective, randomized, controlled, clinical trial to investigate the effect of brief interventions for alcohol abuse on the progression of alcoholic pancreatitis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Witt, H., Apte, M. V., Keim, V. & Wilson, J. S. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 132, 1557–1573 (2007).

    CAS  Article  Google Scholar 

  2. 2

    Apte, M. V. & Wilson, J. S. Mechanisms of pancreatic fibrosis. Dig. Dis. 22, 273–279 (2004).

    CAS  Google Scholar 

  3. 3

    Apte, M. V., Pirola, R. C. & Wilson, J. S. Where there's smoke there's not necessarily fire. Gut 54, 446–447 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Maisonneuve, P. et al. Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. Gut 54, 510–514 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Vonlaufen, A. et al. Bacterial endotoxin—a trigger factor for alcoholic pancreatitis? Findings of a novel physiologically relevant model. Gastroenterology 133, 1293–1303 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Bhardwaj, P. et al. A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology 136, 149–159 e2 (2009).

    Article  Google Scholar 

  7. 7

    Gullo, L., Barbara, L. & Labo, G. Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology 95, 1063–1068 (1988).

    CAS  Article  Google Scholar 

  8. 8

    Strum, W. B. Abstinence in alcoholic chronic pancreatitis. Effect on pain and outcome. J. Clin. Gastroenterol. 20, 37–41 (1995).

    CAS  Article  Google Scholar 

  9. 9

    Nordback, I. et al. The recurrence of acute alcohol-associated pancreatitis can be reduced: a randomized controlled trial. Gastroenterology 136, 848–855 (2009).

    Article  Google Scholar 

  10. 10

    Kaner, E. F. et al. Effectiveness of brief alcohol interventions in primary care populations. Cochrane Database of Systematic Reviews, Issue 2. Art. no CD004148. doi:10.1002/14651858.

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jeremy S. Wilson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Apte, M., Pirola, R. & Wilson, J. Alcoholic pancreatitis—it's the alcohol, stupid. Nat Rev Gastroenterol Hepatol 6, 321–322 (2009). https://doi.org/10.1038/nrgastro.2009.84

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing