News & Views | Published:


Antioxidants for pain relief in chronic pancreatitis

Nature Reviews Gastroenterology & Hepatology volume 6, pages 262263 (2009) | Download Citation

In a study carried out in India, antioxidant therapy for chronic pancreatitis offered short-term benefits and was associated with few adverse events. Although the etiology and characteristics of this condition vary between countries, antioxidant therapy could be implemented as an adjunct treatment in the early inflammatory phase of chronic pancreatitis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , , & Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 132, 1557–1573 (2007).

  2. 2.

    , & Fernández- AGA technical review: treatment of pain in chronic pancreatitis. Gastroenterology 115, 765–776 (1998).

  3. 3.

    , , & Micronutrient antioxidant status in tropical compared with temperate-zone chronic pancreatitis. Scand. J. Gastroenterol. 28, 1098–1104 (1993).

  4. 4.

    et al. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. Aliment. Pharmacol. Ther. 6, 229–240 (1992).

  5. 5.

    et al. Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J. Gastrointest. Surg. 10, 499–503 (2006).

  6. 6.

    et al. A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology 136, 149–159 (2009).

  7. 7.

    et al. Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis. Br. J. Surg. 90, 1565–1572 (2003).

  8. 8.

    Natural course of chronic pancreatitis. Pancreatology 1, 3–14 (2001).

Download references

Author information


  1. Department of General and Visceral Surgery, University of Heidelberg, Germany.

    • Jens Werner
    •  & Markus W. Büchler


  1. Search for Jens Werner in:

  2. Search for Markus W. Büchler in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Markus W. Büchler.

About this article

Publication history



Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing