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Gene expression

Environmental noise control

Nature Reviews Genetics volume 16, pages 624–625 (2015)Cite this article

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The authors employed a library of 859 S. cerevisiae strains that each contained a different yeast promoter fused to a fluorescent protein and used flow cytometry to determine both the mean expression and expression noise for each reporter fusion under 4 different environmental conditions. Expression noise differed significantly between growth conditions, and this effect was dependent on growth rate; most promoters, regardless of expression values, displayed increased noise under nutrient-limited conditions that support low growth rates.

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References

  1. Keren, L. et al. Noise in gene expression is coupled to growth rate. Genome Res. http://dx.doi.org/10.1101/gr.191635.115 (2015)

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  1. Denise Waldron
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Waldron, D. Environmental noise control. Nat Rev Genet 16, 624–625 (2015). https://doi.org/10.1038/nrg4021

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