An ecosystem of cancer cell line factories to support a cancer dependency map


Jesse Boehm and Todd Golub call for an international effort to establish >10,000 cancer cell line models as a community resource. Cancer cell line factories will facilitate the creation of a cancer dependency map, connecting cancer genomics to therapeutic dependencies.

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  1. 1

    Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495–501 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603–607 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483, 570–575 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Liu, X. et al. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am. J. Pathol. 180, 599–607 (2012).

    CAS  Article  Google Scholar 

  5. 5

    van de Wetering, M. et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161, 933–945 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Jesse S. Boehm.

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The authors declare no competing financial interests.

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Cell Line Factory portal

Global Alliance for Genomics and Health

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Boehm, J., Golub, T. An ecosystem of cancer cell line factories to support a cancer dependency map. Nat Rev Genet 16, 373–374 (2015).

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