This study describes the 'integrative personal omics profile' (iPOP) of a healthy person — that of Mike Snyder, an author on the paper — which was generated by combining a whole-genome sequence with transcriptomic, proteomic, metabolomic and autoantibody data sampled over 14 months. As well as highlighting the subject's predisposition to type 2 diabetes, the study also identified new immune pathways that are activated by viral infection. Despite the complexity of analysing large and varied data sets, this paper is proof-of-principle that iPOPs are useful for gaining insights into physiological states and for assessing disease risk.