Through a comparison of genome-wide nucleosome occupancy maps from 13 species of fungi, these authors provide insight into the relationship between genome evolution and chromatin structure. Although they found substantial conservation across species in levels of nucleosome depletion at many sites, they also found important differences among species in the roles played by sequence or trans-acting factors in determining nucleosome positioning. This work suggests evolutionary plasticity in regulation of chromatin structure.
ORIGINAL RESEARCH PAPER
Tsankav, A. et al. Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization. Genome Res. 13 Sep 2011 (doi:10.1101/gr.122267.111)
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Muers, M. An evolutionary perspective on nucleosome positioning. Nat Rev Genet 12, 741 (2011). https://doi.org/10.1038/nrg3100
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DOI: https://doi.org/10.1038/nrg3100