Marbach et al. have developed a novel resource of 394 human cell type- and tissue-specific gene regulatory networks, representing 146 different cell types, 111 tissues and 137 cell lines. Transcriptional regulatory circuits were inferred on the basis of expression profiles of enhancers and promoters, their integration with transcription factor sequence motifs, and linking of regulatory elements with target genes on the basis of genomic distance and joint expression in a given tissue. Analysis of data from across 37 genome-wide association studies (GWAS) revealed that disease-related variants often disrupt network modules that are specific for trait-relevant tissues, which suggests that perturbed regulatory modules can help define disease-relevant tissues. All networks and tools are freely available at http://regulatorycircuits.org.