Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mitchochondrial replacement therapy: the IOM report and its aftermath

Glenn Cohen and Eli Adashi comment on recommendations and limitations of the Institute of Medicine (IOM) report on mitochondrial replacement therapies in light of recent legislative changes in the United States of America.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. National Academies of Sciences, Engineering, and Medicine. Mitochondrial replacement techniques: ethical, social, and policy considerations. (The National Academies Press, 2016).

  2. Herbert, M. & Turnbull, D. Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease. EMBO Rep. 16, 539–540 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. Cohen, I. G., Savulescu, J. & Adashi, E. Y. Transatlantic lessons in regulation of mitochondrial replacement therapy. Science 348, 178–80 (2015).

    CAS  Article  PubMed  Google Scholar 

  4. The President's Council on Bioethics. Beyond therapy: biotechnology and the pursuit of happiness [online], (2003)

  5. Consolidated Appropriations Act, 2016. Sec. 749. [online], (2015).

  6. Cohen, C. I. The constitution and the rights not to procreate. Stanford Law Rev. 60, 1135–1196 (2008).

    Google Scholar 

  7. Foreign Assistance Act, 1973. Pub. L. No. 93-189, 87 stat. 714 (1973).

  8. Departments of Labor and Health, Education, and Welfare Appropriation Act, 1977. Pub. L. No. 94-439, 209, 90 Stat. 1418, 1434 (1976).

  9. The Balanced Budget Downpayment Act, I, Pub. L. No. 104-99, § 128, 110 Stat. 26, 34 (1996).

Download references


I.G.C. is supported by the Greenwall Foundation Faculty Scholars Program in Bioethics Award.

Author information

Authors and Affiliations


Corresponding author

Correspondence to I. Glenn Cohen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Cohen, I., Adashi, E. Mitchochondrial replacement therapy: the IOM report and its aftermath. Nat Rev Genet 17, 189–190 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing