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Surgery

The new gold-standard — medical gastric bypass

Nature Reviews Endocrinology volume 14, pages 257–258 (2018)Cite this article

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A recent randomized controlled clinical trial with 5-year follow-up demonstrates the impressive effectiveness of the combination of metabolic surgery with medical therapies and shifts the paradigm in the care of patients with obesity and type 2 diabetes mellitus.

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References

  1. Ikramuddin, S. et al. Lifestyle intervention and medical management with versus without Roux-en-Y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic blood pressure at 5 years in the Diabetes Surgery Study. JAMA 319, 266–278 (2018).

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  2. Reges, O. et al. Association of bariatric surgery using laparoscopic banding, Roux-en-Y gastric bypass, or laparoscopic sleeve gastrectomy versus usual care obesity management with all-cause mortality. JAMA 319, 279–290 (2018).

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  3. Sjostrom, L. et al. Bariatric surgery and long-term cardiovascular events. JAMA 307, 56–65 (2012).

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  4. Lean, M. E. J. et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet 391, 541–551 (2018).

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Authors and Affiliations

  1. Academic Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, London, UK

    Alexander D. Miras & Carel W. le Roux

  2. Diabetes Complications Research Centre, Conway Institute, University College, Dublin, Ireland

    Carel W. le Roux

Authors
  1. Alexander D. Miras
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  2. Carel W. le Roux
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Corresponding author

Correspondence to Carel W. le Roux.

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Competing interests

C.W.l.R is on the advisory boards for Johnson & Johnson, Fractyl, GI, Dynamics, NovoNordisk and Herbalife. A.M has received research grants or honoraria from Fractyl, Johnson & Johnson, NovoNordisk, Astrazeneca and Boehringer Ingelheim

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Miras, A., le Roux, C. The new gold-standard — medical gastric bypass. Nat Rev Endocrinol 14, 257–258 (2018). https://doi.org/10.1038/nrendo.2018.28

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