News & Views | Published:

Diabetes: Peripheral nerve modulation to treat metabolic disease

Nature Reviews Endocrinology volume 14, pages 193194 (2018) | Download Citation

Diabetes mellitus therapies aim to reduce disease complications, such as nephropathy, by achieving long-term blood glucose regulation, but actually doing so is difficult. A recent study by Sacramento and colleagues has applied electronic modulation of nerve activity in rodents as an approach to treat diabetes mellitus.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from $8.99

All prices are NET prices.

References

  1. 1.

    & Gut hormones as therapeutic agents in treatment of diabetes and obesity. Curr. Opin. Pharmacol. 13, 996–1001 (2013).

  2. 2.

    et al. Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes. Diabetologia 61, 700–710 (2018).

  3. 3.

    , & Effects of high potassium on the release of [3H]dopamine from the cat carotid body in vitro. J. Physiol. 379, 293–307 (1986).

  4. 4.

    & Carotid sinus receptors participate in glucose homeostasis. Respir. Physiol. 72, 347–359 (1988).

  5. 5.

    et al. Role of the carotid body chemoreceptors in glucose homeostasis and thermoregulation in humans. J. Physiol. (2018).

  6. 6.

    & Low glucose-sensing cells in the carotid body. Nat. Neurosci. 5, 197–198 (2002).

  7. 7.

    , & Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J. Physiol. 578, 735–750 (2007).

  8. 8.

    , & Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat. J. Physiol. 556, 255–266 (2004).

  9. 9.

    et al. Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. Diabetologia 60, 158–168 (2017).

  10. 10.

    & Appetite signaling: from gut peptides and enteric nerves to brain. Physiol. Behav. 92, 256–262 (2007).

Download references

Acknowledgements

S.A.S. is supported by NIH (MH105941 and 1R01NS097184), American Diabetes Association (ADA #1-17-ACE-31), Einstein-Mt. Sinai Diabetes Research Center Pilot and Feasibility award (P30DK020541) and Alexander and Alexandrine Sinsheimer Scholar Award.

Author information

Affiliations

  1. Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

    • Sarah A. Stanley

Authors

  1. Search for Sarah A. Stanley in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Sarah A. Stanley.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nrendo.2018.21