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Diabetes

Loss of β-cell mass — an acute event before T1DM presentation?

Nature Reviews Endocrinology volume 13, pages 253–254 (2017)Cite this article

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Loss of β-cell mass is posited to occur gradually over a long period of time in preclinical type 1 diabetes mellitus, as the first signs of β-cell autoimmunity generally emerge several years before clinical presentation. This concept has recently been challenged by observations of acute loss of β-cell mass in late-phase preclinical disease.

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Authors and Affiliations

  1. Department of Paediatrics, Children's Hospital, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014, Helsinki, Finland

    Mikael Knip

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  1. Mikael Knip
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Correspondence to Mikael Knip.

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Competing interests

M.K. declares that he has received a lecture fee from Merck Sharpe & Dohme (MSD), and that he is a board member and minor share holder (<5%) of Vactech Oy.

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Knip, M. Loss of β-cell mass — an acute event before T1DM presentation?. Nat Rev Endocrinol 13, 253–254 (2017). https://doi.org/10.1038/nrendo.2017.33

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