Immunometabolism in 2017

Metabolism and the inflammasome in health and ageing

Extracellular danger-associated molecular patterns signal to NOD-like receptors, but the exact signalling pathways remain unclear. The inflammasomes, a subgroup of these receptors, translate danger signals into inflammatory responses by maturing IL-1 and IL-18. In 2017, researchers reported novel functions of the mutual interaction between metabolism and the inflammasomes in health and disease.

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Figure 1: The inflammasome and metabolism in homeostasis and inflammageing.

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Correspondence to Thomas Mandrup-Poulsen.

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Mandrup-Poulsen, T. Metabolism and the inflammasome in health and ageing. Nat Rev Endocrinol 14, 72–74 (2018). https://doi.org/10.1038/nrendo.2017.175

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