Development of safe and potent therapeutics is required to combat the obesity and diabetes mellitus pandemic
Animal models remain indispensable for discovering, validating and optimizing novel therapeutics for their safe use in humans
To improve the transition from bench to bedside, researchers must select the appropriate models, beware a myriad of confounding factors and draw appropriate conclusions
Experimental procedures and conditions should be accurately detailed to improve the reproducibility and translation of findings in preclinical animal models
Different animal models, ranging from non-mammalian models to non-human primates, each have distinct advantages and limitations
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.
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The authors declare no competing financial interests.
- Amphid neuron
Sensory neurons found in the anterior head region of the nematode Caenorhabditis elegans.
- Four core genotypes
A mouse model system that dissociates the effects of the gonadal sex (testes or ovaries) from the effects of the sex chromosomes (XX or XY)121.
Factors that are exogenous to an organism.
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Kleinert, M., Clemmensen, C., Hofmann, S. et al. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol 14, 140–162 (2018). https://doi.org/10.1038/nrendo.2017.161
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