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Bone diseases

Romosozumab — on track or derailed?

Romosozumab, a recently developed sclerostin inhibitor, stimulates bone formation and inhibits bone resorption, thereby markedly increasing bone mass and reducing fracture risk. But will a red flag regarding possible adverse cardiovascular events derail this promising new drug for osteoporosis?

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The author's work is supported by NIH grants AG004875, AG048792 and AR027065. In addition, the author greatly appreciates the critical review of this article by M. Drake and J. Farr.

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Correspondence to Sundeep Khosla.

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The author declares no competing financial interests.

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Khosla, S. Romosozumab — on track or derailed?. Nat Rev Endocrinol 13, 697–698 (2017).

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