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Paediatric endocrinology

Can niacin supplementation protect against congenital malformations?

Nature Reviews Endocrinology volume 13, pages 630–631 (2017)Cite this article

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A recent report found mutations in the de novo kynurenine pathway and reduced plasma levels of NAD in patients with congenital malformations. In a mouse model, the mutation not only altered the phenotype of the litters but the combination of a homozygous mutation and a niacin-free diet resulted in miscarriages.

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References

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Authors and Affiliations

  1. Melanie Penke is at the Center for Pediatric Research Leipzig, University Hospital for Children & Adolescents, University of Leipzig, Liebigstraße 19, 04103 Leipzig, Germany.,

    Melanie Penke

  2. Wieland Kiess is at the Center for Pediatric Research Leipzig, University Hospital for Children & Adolescents, University of Leipzig, Liebigstraße 19, 04103 Leipzig, Germany,

    Wieland Kiess

  3. Department of Women & Child Health, and at the Hospital for Children and Adolescents, University of Leipzig, Liebigstraße 20a, D 04103 Leipzig, Germany.,

    Wieland Kiess

Authors
  1. Melanie Penke
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  2. Wieland Kiess
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Correspondence to Wieland Kiess.

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The authors declare no competing financial interests.

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Penke, M., Kiess, W. Can niacin supplementation protect against congenital malformations?. Nat Rev Endocrinol 13, 630–631 (2017). https://doi.org/10.1038/nrendo.2017.133

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