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Exercise metabolism in 2016

Health benefits of exercise — more than meets the eye!

Although regular physical activity can prevent or reduce the risk of many age-related diseases, the molecular mechanisms underpinning the protective effects of exercise are largely unknown. In 2016, a series of studies demonstrated that crosstalk between tissues during exercise can protect against metabolic disease, cancer, retinal degeneration and memory loss. These studies provide a molecular basis for the concept of 'exercise as medicine'.

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Figure 1: The multiple benefits of exercise.


  1. Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8, 457–465 (2012).

    CAS  Article  Google Scholar 

  2. Booth, F. W., Roberts, C. K. & Laye, M. J. Lack of exercise is a major cause of chronic diseases. Compr. Physiol. 2, 1143–1211 (2012).

    PubMed  PubMed Central  Google Scholar 

  3. Whitham, M. & Febbraio, M. A. The ever-expanding myokinome: discovery challenges and therapeutic implications. Nat. Rev. Drug Discov. 15, 719–729 (2016).

    CAS  Article  Google Scholar 

  4. Moon, H. Y. et al. Running-induced systemic cathepsin B secretion is associated with memory function. Cell Metab. 24, 332–340 (2016).

    CAS  Article  Google Scholar 

  5. Mera, P. et al. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 23, 1078–1092 (2016).

    CAS  Article  Google Scholar 

  6. Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P. & Pedersen, B. K. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53, 1643–1648 (2004).

    CAS  Article  Google Scholar 

  7. van Hall, G. et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J. Clin. Endocrinol. Metab. 88, 3005–3010 (2003).

    CAS  Article  Google Scholar 

  8. Thompson, H. J., Jiang, W. & Zhu, Z. Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life 61, 895–901 (2009).

    CAS  Article  Google Scholar 

  9. Pedersen, L. et al. Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metab. 23, 554–562 (2016).

    CAS  Article  Google Scholar 

  10. Chrysostomou, V. et al. Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway. Aging Cell 15, 1082–1091 (2016).

    CAS  Article  Google Scholar 

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The author is a senior principal research fellow of The National Health and Medical Research Council of Australia (supported by grant APP11021168).

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Correspondence to Mark A. Febbraio.

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The author declares no competing financial interests.

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Febbraio, M. Health benefits of exercise — more than meets the eye!. Nat Rev Endocrinol 13, 72–74 (2017).

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