Obesity and ageing are major worldwide health challenges associated with lifestyle changes and an increase in age-related diseases, characterized by chronic inflammation dubbed metaflammation and inflammaging. However, the mechanistic link between these inflammatory processes is still unknown. New findings in 2016 shed light on these issues and indicate common targets for intervention.
Subscribe to Journal
Get full journal access for 1 year
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Kennedy, B. K. et al. Geroscience: linking aging to chronic disease. Cell 159, 709–713 (2014).
Franceschi, C. & Campisi, J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. A Biol. Sci. Med. Sci. 69 (Suppl. 1), 4–9 (2014).
Franceschi, C. et al. Inflammaging and 'garb-aging'. Trends Endocrinol. Metab. http://dx.doi.org/10.1016/j.tem.2016.09.005 (2016).
Gregor, M. F. & Hotamisligil, G. S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 29, 415–445 (2011).
Schafer, M. J. et al. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes 65, 1606–1615 (2016).
Shirakawa, K. et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J. Clin. Invest. 126, 4626–4639 (2016).
Hall, B. M. et al. Aging of mice is associated with p16Ink4a- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells. Aging (Albany NY) 8, 1294–1315 (2016).
Yang, L. et al. Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle. Cell Rep. 14, 422–428 (2016).
Collins, K. H. et al. A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats. Sci. Rep. 6, 37278 (2016).
Biagi, E. et al. Gut microbiota and extreme longevity. Curr. Biol. 26, 1480–1485 (2016).
This work was supported by the European Union (EU)'s H2020 Project 'Propag-ageing' (grant agreement no. 634821), EU FP7 “HUMAN”, G.A. n. 602757; and EU JPND 'Adage' to C.F.
The author declares no competing financial interests.
About this article
Cite this article
Franceschi, C. Obesity in geroscience — is cellular senescence the culprit?. Nat Rev Endocrinol 13, 76–78 (2017). https://doi.org/10.1038/nrendo.2016.213
Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
Immunity & Ageing (2020)
Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study
European Radiology (2019)