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Healthy ageing in 2016

Obesity in geroscience — is cellular senescence the culprit?

Obesity and ageing are major worldwide health challenges associated with lifestyle changes and an increase in age-related diseases, characterized by chronic inflammation dubbed metaflammation and inflammaging. However, the mechanistic link between these inflammatory processes is still unknown. New findings in 2016 shed light on these issues and indicate common targets for intervention.

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Figure 1: A nutrient-rich, high-fat diet induces accumulation in visceral adipose tissue of senescent immune cells (macrophages and T cells).

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Acknowledgements

This work was supported by the European Union (EU)'s H2020 Project 'Propag-ageing' (grant agreement no. 634821), EU FP7 “HUMAN”, G.A. n. 602757; and EU JPND 'Adage' to C.F.

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Correspondence to Claudio Franceschi.

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The author declares no competing financial interests.

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Franceschi, C. Obesity in geroscience — is cellular senescence the culprit?. Nat Rev Endocrinol 13, 76–78 (2017). https://doi.org/10.1038/nrendo.2016.213

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