Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Diabetes

Intravitreous ranibizumab for proliferative diabetic retinopathy

The Diabetic Retinopathy Clinical Research Network has published the 2-year results of a 5-year study comparing intravitreous ranibizumab with panretinal laser photocoagulation in patients with proliferative diabetic retinopathy. The results suggest that intravitreous ranibizumab will become a valuable treatment option, although its exact role remains to be defined.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. The Diabetic Retinopathy Study Research Group. Preliminary report on effects of photocoagulation therapy. Am. J. Ophthalmol. 81, 383–396 (1976).

  2. The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8. Ophthalmology 88, 583–600 (1981).

  3. Fine, S. L. & Patz, A. Ten years after the Diabetic Retinopathy Study. Ophthalmology 94, 739–740 (1987).

    Article  CAS  Google Scholar 

  4. James, S., Gallagher, R., Dunbabin, J. & Perry, L. Prevalence of vascular complications and factors predictive of their development in young adults with type 1 diabetes: systematic literature review. BMC Res. Notes 7, 593 (2014).

    Article  CAS  Google Scholar 

  5. Michaelides, M. et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology 117, 1078–1086 (2010).

    Article  Google Scholar 

  6. National Institute for Health and Care Excellence. Aflibercept for treating diabetic macular oedema. NICE technology appraisal guidance [TA346] [online], (2015).

  7. National Institute for Health and Care Excellence. Ranibizumab for treating diabetic macular oedema. NICE technology appraisal guidance [TA274] [online], (2013).

  8. Writing Committee for the Diabetic Retinopathy Clinical Research Network. Panretinal photocoagulation versus intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA 314, 2137–2146 (2015).

  9. Sivaprasad, S. et al. Clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy (acronym CLARITY): a multicentre phase IIb randomised active-controlled clinical trial. BMJ Open 5, e008405 (2015).

    Article  Google Scholar 

  10. US National Library of Medicine. ClinicalTrials.gov[online], (2015).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan M. Gibson.

Ethics declarations

Competing interests

J.M.G. has received travel honoraria for conferences and consultancy fees for attending Advisory Boards from Allergan, Alimera, Bayer Healthcare and Novartis UK Ltd, and research funding from Novartis UK. S.M. has no competing interests to declare.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gibson, J., McGinnigle, S. Intravitreous ranibizumab for proliferative diabetic retinopathy. Nat Rev Endocrinol 12, 130–131 (2016). https://doi.org/10.1038/nrendo.2016.1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2016.1

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing