Early attempts at the reinduction of 131I uptake by redifferentiation of 131I-negative differentiated thyroid cancer (DTC) had limited success. Novel therapies targeting the pathways that restore expression of the sodium iodine symporter now offer new hope of success for redifferentiation therapy in DTCs with the BRAFV600E mutation.
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F.A.V. has been a consultant for Bayer Healthcare and Sanofi Genzyme and received speaker honoraria from Diasorin and Sanofi Genzyme. M.L. has been a consultant for AstraZeneca, Bayer Healthcare, Sanofi Genzyme and Sobi and received speaker honoraria and research support from Henning, Sanofi Genzyme and Merck.
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Verburg, F., Luster, M. Redifferentiation — a 'new' option for 131I-negative DTC. Nat Rev Endocrinol 13, 9–10 (2017). https://doi.org/10.1038/nrendo.2016.182
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DOI: https://doi.org/10.1038/nrendo.2016.182
