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Endocrine disruptors in 2015

Epigenetic transgenerational inheritance

Endocrine disruptors are critical environmental exposures that influence health and can promote epigenetic transgenerational inheritance of disease and abnormal physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on human disease, further examples of endocrine disruptors promoting transgenerational behavioural effects, insights into effects of endocrine disruptors on epigenetic programming of primordial germ cells and the finding that endocrine disruptors can transgenerationally promote genetic mutations.

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Figure 1: Endocrine-disruptor-induced epigenetic transgenerational inheritance.


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The author's work is supported by grants from the NIH and the Templeton Foundation.

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Correspondence to Michael K. Skinner.

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The author declares no competing financial interests.

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Skinner, M. Epigenetic transgenerational inheritance. Nat Rev Endocrinol 12, 68–70 (2016).

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