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Adipose tissue biology in 2014

Advances in our understanding of adipose tissue homeostasis

In 2014, numerous noteworthy papers focusing on adipose tissue physiology were published. Many of these articles showed the promise of adipose-tissue-targeted approaches for therapeutic intervention in obesity and type 2 diabetes mellitus. Here, we highlight advances in the development and maintenance of brown and/or beige adipocytes and the metabolic implications of inflammation in adipose tissues.

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References

  1. Nedergaard, J., Bengtsson, T. & Cannon, B. Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293, E444–E452 (2007).

    Article  CAS  Google Scholar 

  2. Harms, M. & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252–1263 (2013).

    Article  CAS  Google Scholar 

  3. Long, J. Z. et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 19, 810–820 (2014).

    Article  CAS  Google Scholar 

  4. Conboy, I. M., Conboy, M. J., Smythe, G. M. & Rando, T. A. Notch-mediated restoration of regenerative potential to aged muscle. Science 302, 1575–1577 (2003).

    Article  CAS  Google Scholar 

  5. Osathanon, T., Subbalekha, K., Sastravaha, P. & Pavasant, P. Notch signalling inhibits the adipogenic differentiation of single-cell-derived mesenchymal stem cell clones isolated from human adipose tissue. Cell Biol. Int. 36, 1161–1170 (2012).

    Article  CAS  Google Scholar 

  6. Bi, P. et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat. Med. 20, 911–918 (2014).

    Article  CAS  Google Scholar 

  7. Mori, M. A. et al. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 16, 336–347 (2012).

    Article  CAS  Google Scholar 

  8. Mori, M. A. et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J. Clin. Invest. 124, 3339–3351 (2014).

    Article  CAS  Google Scholar 

  9. Ramkhelawon, B. et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat. Med. 20, 377–384 (2014).

    Article  CAS  Google Scholar 

  10. Wernstedt Asterholm, I. et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20, 103–118 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge support from the NIH (Grants R01-DK55758, R01-DK099110 and P01-DK088761 [P.E.S.], T32-DK007307 [J.H.S.]).

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Correspondence to Philipp E. Scherer.

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The authors declare no competing financial interests.

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Stern, J., Scherer, P. Advances in our understanding of adipose tissue homeostasis. Nat Rev Endocrinol 11, 71–72 (2015). https://doi.org/10.1038/nrendo.2014.219

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