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Genetics of adrenal diseases in 2014

Genetics improves understanding of adrenocortical tumours

2014 has seen advances in our understanding of benign and malignant tumours of the adrenal cortex, particularly in Cushing syndrome. Modern genetics has generated a flurry of data. The challenge is to give sense to them; however, the difficulties of collecting the clinical data must not be underestimated.

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Figure 1: A global overview of the major genes that have a pathophysiological role in the various tumours that primarily originate from the adrenal gland.

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Correspondence to Xavier Bertagna.

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Bertagna, X. Genetics improves understanding of adrenocortical tumours. Nat Rev Endocrinol 11, 77–78 (2015). https://doi.org/10.1038/nrendo.2014.215

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