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Vitamin D and type 2 diabetes mellitus—hype or hope?

Vitamin D deficiency is a global health concern, which might affect the pathogenesis of diabetes mellitus. Previous studies suggest vitamin D has some potential in the treatment of type 2 diabetes mellitus. A new combined genetic study and meta-analysis reveals conflicting results regarding the effects of circulating levels of vitamin D on type 2 diabetes mellitus risk.

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References

  1. Muscogiuri, G. et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur. J. Endocrinol. 171, R101–R110 (2014).

    Article  CAS  Google Scholar 

  2. Ye, Z. et al. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol. http://dx.doi.org/10.1016/S2213-8587(14)70184-6.

  3. Wang, T. J. et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, 180–188 (2010).

    Article  CAS  Google Scholar 

  4. Cooper, J. D. et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 60, 1624–1631 (2011).

    Article  CAS  Google Scholar 

  5. Shea, M. K. et al. Genetic and non-genetic correlates of vitamins K and D. Eur. J. Clin. Nutr. 63, 458–464 (2009).

    Article  CAS  Google Scholar 

  6. Gagnon, C. et al. Effects of combined calcium and vitamin D supplementation on insulin secretion, insulin sensitivity and β-cell function in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes: a pilot randomized, placebo-controlled trial. PLoS ONE 9, e109607 (2014).

    Article  Google Scholar 

  7. Vimaleswaran, K. S. et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2, 719–729 (2014).

    Article  CAS  Google Scholar 

  8. Strobel, F. et al. Effect of a randomised controlled vitamin D trial on insulin resistance and glucose metabolism in patients with type 2 diabetes mellitus. Horm. Metab. Res. 46, 54–58 (2014).

    CAS  PubMed  Google Scholar 

  9. Strawbridge, R. J. et al. A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness). Diabetologia 57, 1159–1172 (2014).

    CAS  PubMed  Google Scholar 

  10. Wong, M. S. et al. Vitamin D promotes vascular regeneration. Circulation 130, 976–986 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

K.B. is supported by the European Community Health Seventh Framework Programme (FP7/2009–2014 under grant agreement 241447 with acronym NAIMIT) and the Else-Kröner-Fresenius Foundation–postgraduate program (TRIP).

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Correspondence to Klaus Badenhoop.

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Badenhoop, K. Vitamin D and type 2 diabetes mellitus—hype or hope?. Nat Rev Endocrinol 11, 10–11 (2015). https://doi.org/10.1038/nrendo.2014.206

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