Biason-Lauber et al. have identified a SIRT1 mutation in patients with type 1 diabetes mellitus (T1DM). Considering that SIRT1 can inhibit autoimmunity and the SIRT1 mutation enhances autoimmune reactions, the work links genetic SIRT1 alteration to the pathogenesis of T1DM and suggests SIRT1 as a potential therapeutic target for T1DM.
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Chong, Z. Implications of a novel point mutation of SIRT1 in T1DM. Nat Rev Endocrinol 9, 323–324 (2013). https://doi.org/10.1038/nrendo.2013.87
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DOI: https://doi.org/10.1038/nrendo.2013.87
