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Puberty in 2013

Unravelling the mystery of puberty

Nature Reviews Endocrinology volume 10, pages 6769 (2014) | Download Citation

In 2013, considerable progress was made towards deciphering the molecular foundations of puberty. Loss of transcriptional repression was identified as a core mechanism underlying the onset of puberty, and this loss was found to be precipitated by epigenetic cues. It was also discovered that nutritional deprivation delays puberty by repressing reproductive neuroendocrine function.

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The authors' work is supported by a grant from the USA National Science Foundation (IOS1121691).

Author information


  1. Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

    • Sergio R. Ojeda
    •  & Alejandro Lomniczi


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The authors declare no competing financial interests.

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Correspondence to Sergio R. Ojeda.

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