In 2013, considerable progress was made towards deciphering the molecular foundations of puberty. Loss of transcriptional repression was identified as a core mechanism underlying the onset of puberty, and this loss was found to be precipitated by epigenetic cues. It was also discovered that nutritional deprivation delays puberty by repressing reproductive neuroendocrine function.
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The authors' work is supported by a grant from the USA National Science Foundation (IOS1121691).
The authors declare no competing financial interests.
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Ojeda, S., Lomniczi, A. Unravelling the mystery of puberty. Nat Rev Endocrinol 10, 67–69 (2014). https://doi.org/10.1038/nrendo.2013.233
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