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Obesity

Can inflammatory status define metabolic health?

Nature Reviews Endocrinology volume 9, pages 694–695 (2013)Cite this article

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A recent study shows that inflammation could be the underlying factor that determines the differences in metabolic profiles between subgroups of obesity. An improved understanding and characterization of these subgroups should help to develop innovative approaches to treat obesity.

The study included 2,040 white men and women aged 50–69 years who were classified as obese or nonobese on the basis of their BMI. The participants were further subdivided according to metabolic health status (healthy or unhealthy), which was defined using five existing metabolic health definitions on the basis of different cardiometabolic abnormalities. Phillips and Perry measured a wide range of circulating inflammatory markers, such as proinflammatory cytokines, adipokines and acute-phase response proteins. In addition, the investigators examined the association between the inflammatory profile and metabolic health among four groups: MHO; MUO; MUNO; and metabolically healthy and nonobese individuals.

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Authors and Affiliations

  1. Department of Kinanthropology, Université du Québec à Montréal, Case postale 8888, Succursale Centre-Ville, Montréal, H3C 3P8, QC, Canada

    Antony D. Karelis

  2. Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, H2W 1R7, QC, Canada

    Rémi Rabasa-Lhoret

Authors
  1. Antony D. Karelis
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  2. Rémi Rabasa-Lhoret
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Correspondence to Rémi Rabasa-Lhoret.

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The authors declare no competing financial interests.

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Karelis, A., Rabasa-Lhoret, R. Can inflammatory status define metabolic health?. Nat Rev Endocrinol 9, 694–695 (2013). https://doi.org/10.1038/nrendo.2013.198

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  • DOI: https://doi.org/10.1038/nrendo.2013.198

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