Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Obesity

Can inflammatory status define metabolic health?

A recent study shows that inflammation could be the underlying factor that determines the differences in metabolic profiles between subgroups of obesity. An improved understanding and characterization of these subgroups should help to develop innovative approaches to treat obesity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Karelis, A. D., St-Pierre, D. H., Conus, F., Rabasa-Lhoret, R. & Poehlman, E. T. Metabolic and body composition factors in subgroups of obesity: what do we know? J. Clin. Endocrinol. Metab. 89, 2569–2575 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Wildman, R. P. et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999–2004). Arch. Intern. Med. 168, 1617–1624 (2008).

    Article  PubMed  Google Scholar 

  3. Calori, G. et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care 34, 210–215 (2011).

    Article  PubMed  Google Scholar 

  4. Hamer, M. & Stamatakis, E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J. Clin. Endocrinol. Metab. 97, 2482–2488 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Meigs, J. B. et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J. Clin. Endocrinol. Metab. 91, 2906–2912 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Phillips, C. M. & Perry, I. J. Does inflammation determine metabolic health status in obese and nonobese adults? J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2013-2038.

  7. Karelis, A. D. et al. The metabolically healthy but obese Individual presents a favourable inflammation profile. J. Clin. Endocrinol. Metab. 90, 4145–4150 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Shin, M. J. et al. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int. J. Obes. (Lond.) 30, 1529–1534 (2006).

    Article  CAS  Google Scholar 

  9. Primeau, V. et al. Characterizing the profile of obese patients who are metabolically healthy. Int. J. Obes. (Lond.) 35, 971–981 (2011).

    Article  CAS  Google Scholar 

  10. Velho, S., Paccaud, F., Waeber, G., Vollenweider, P. & Marques-Vidal, P. Metabolically healthy obesity: different prevalences using different criteria. Eur. J. Clin. Nutr. 64, 1043–1051 (2010).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rémi Rabasa-Lhoret.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karelis, A., Rabasa-Lhoret, R. Can inflammatory status define metabolic health?. Nat Rev Endocrinol 9, 694–695 (2013). https://doi.org/10.1038/nrendo.2013.198

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2013.198

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing